Accumulation of intracellular HCO3- by Na(+)-HCO3- cotransport in interlobular ducts from guinea-pig pancreas.
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چکیده
منابع مشابه
Functional coupling of apical Cl-/HCO3- exchange with CFTR in stimulated HCO3- secretion by guinea pig interlobular pancreatic duct.
Pancreatic ductal epithelium produces a HCO(3)(-)-rich fluid. HCO(3)(-) transport across ductal apical membranes has been proposed to be mediated by both SLC26-mediated Cl(-)/HCO(3)(-) exchange and CFTR-mediated HCO(3)(-) conductance, with proportional contributions determined in part by axial changes in gene expression and luminal anion composition. In this study we investigated the characteri...
متن کاملMembrane Potential and Bicarbonate Secretion in Isolated Interlobular Ducts from Guinea-pig Pancreas
The interlobular duct cells of the guinea-pig pancreas secrete HCO(3)(-) across their luminal membrane into a HCO(3)(-)-rich (125 mM) luminal fluid against a sixfold concentration gradient. Since HCO(3)(-) transport cannot be achieved by luminal Cl-/HCO(3)(-) exchange under these conditions, we have investigated the possibility that it is mediated by an anion conductance. To determine whether t...
متن کاملSubstance P inhibits bicarbonate secretion from guinea pig pancreatic ducts by modulating an anion exchanger.
The stimulatory pathways controlling HCO3- secretion by the pancreatic ductal epithelium are well described. However, only a few data are available concerning inhibitory mechanisms, which may play an important role in the physiological control of the pancreas. The aim of this study was to investigate the cellular mechanism by which substance P (SP) inhibits pancreatic ductal HCO3- secretion. Sm...
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The inhibitory control of pancreatic ductal HCO(3)(-) secretion may be physiologically important in terms of limiting the hydrostatic pressure developed within the ducts and in terms of switching off pancreatic secretion after a meal. Substance P (SP) inhibits secretin-stimulated HCO(3)(-) secretion by modulating a Cl(-)-dependent HCO(3)(-) efflux step at the apical membrane of the duct cell (H...
متن کاملImmunolocalization of electroneutral Na-HCO3
HENRIK VORUM, TAE-HWAN KWON, CHRISTIAAN FULTON, BRIAN SIMONSEN, INYEONG CHOI, WALTER BORON, ARVID B. MAUNSBACH, SØREN NIELSEN, AND CHRISTIAN AALKJÆR Department of Medical Biochemistry, Department of Cell Biology, Institute of Anatomy, and Department of Physiology, University of Aarhus, DK-8000 Aarhus C, Denmark; and Department of Cellular and Molecular Physiology, Yale University, New Haven, Co...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1996
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1996.sp021582